Description: Established by EBV transformation of mononuclear cells from the peripheral blood of a 15 year old female. The patient has been diagnosed with Xeroderma pigmentosum (XP) complementation group G, showed no skin cancer or neurologic abnormalities and reduced NK activity. XP is a relatively rare recessively inherited disease with DNA repair deficiency. Fibroblasts from the same individual have been designated XP125LO.

Also Known As:

Species: Human

Tissue: Blood

Growth Properties: Suspension

Morphology: Lymphoblastoid

Growth Medium: RPMI 1640 + 4mM Glutamine + 200 µg/ml Sodium Pyruvate (NaPy) + 15% Heat Inactivated (HI-FBS).

Subculturing Procedure: Maintain cultures between 3-9 x 100,000 cells/ml, dilute every 1-2 days to 3 x 100,000 cells/ml 5%

Release Conditions: No

Depositor: Dr. J. Cole, MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, East Sussex, BN1 9RR

Originator: Yes

References: Nature 1993 363:182, Mutation Res 1992 273:171, Br J Dermatol 1987 116:861

Hyperlink to ECACC Cell Line Data Sheet: 98062328