OX-24
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Description
Description: The hybridoma line OX-24 was developed by immunizing BALB/c mice with Factor H followed by fusion of spleen cells with NS0 mouse myeloma cells. The antibody was shown to detect the human complement control protein, Factor H. OX-24, which is also known as MRC-OX24 was reported to increase cofactor activity of Factor H in Factor I-mediated cleavage of soluble C3b. The antibody inhibited the binding of radioactive-labelled Factor H to surface-bound C3b. OX-23 (ECACC catalogue no. 00010402) was shown to decrease this inhibition.
Also Known As:
Species: Mouse
Growth Medium: RPMI 1640 + 2mM glutamine + 10% FBS
Subculturing Procedure: Maintain cultures between 3-9 x 100,000 cells/ml; 5% CO2; 37°C.
Release Conditions: Yes – commercial organisations are required to complete the ‘Cell Line Release Authorisation for Research Use in Commercial Organisations’ release conditions form
Depositor: Dr. M. Puklavec, Cellular Immunology, Sir William Dunn School of Pathology, Oxford
Originator: Yes
References: Bioscience Reports 1983; 3:1119
Hyperlink to ECACC Cell Line Data Sheet: 00010403
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