REM 885
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Description
Description: Derived from a patient with early onset Alzheimer disease and cerebral amyloid angiopathy (CAA)”, carrying a 6.5 Mb microduplication of the APP gene locus on chromosome 21. This is an EBV-transformed lymphoblastoid cell line.
Also Known As:
Species: Human
Tissue: Lymphocyte
Growth Properties: Suspension
Morphology: Lymphoblastoid
Growth Medium: RPMI 1640 + 2mM Glutamine + 20% Foetal Bovine Serum (FBS).
Subculturing Procedure: Maintain cultures between 300,000 to 900,000 cells/ml; 5% CO2; 37°C
Release Conditions: No
Depositor: Dr N Lemeur, EFS-Normandie, Laboratoire de Cytogenetique, 605 Chemin de la Bretèque, BP 558, 76235 Bois Guillaume, France & Dr. Dominique Campion, INSERM U614-IFRMP, Faculté de Médecine, 22 Boulevard Gambetta, 76183 Rouen Cedex, France
Originator: Yes
References: Rovelet-Lecrux et al: APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 2006, 38(1):24-26.
Hyperlink to ECACC Cell Line Data Sheet: 06070401
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