SK-N-DZ
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Description
Description: Spontaneously transformed cells from a female patient with neuroblastoma. The tumour was derived from a bone marrow metastasis and is tumourigenic in nude mice. Used in the study of MIBG uptake in the diagnosis and treatment of neuroblastoma. MIBG is a derivative of the antihypertensive agent guanethidine and is used as a radiopharmaceutical. SK-N-DZ is characterised by low saturable kinetics and predominant linear pattern of uptake of MIBG, with a poor ability to maintain high intracellular levels of the drug.
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Species: Human
Tissue: Neural (bone marrow metastasis)
Growth Properties: Adherent
Morphology: Neuronal
Growth Medium: DMEM or EMEM (EBSS) + 2mM Glutamine + 1% Non Essential Amino Acids (NEAA) + 10% Foetal Bovine Serum (FBS).
Subculturing Procedure: Split sub-confluent cultures (70-80%) 1:10 i.e. seeding at 1-3×10, 000 cells/cm² using 0.25% trypsin/EDTA; 5% CO2; 37°C.
Release Conditions: No
Depositor:
Originator: No
References: Cancer Res 1993;53:304; Acta Neuropathol 1989;79:217; Int J Oncology 1994;5:1037; J Nat Cancer Inst 1984;73(1):51
Hyperlink to ECACC Cell Line Data Sheet: 94092305
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